Formerly known as iconic, family-friendly interstate stops, many American motels have become places where transience and anonymity often go hand-in-hand. "Murder at the Motel" explores tragic murder cases set in motels and the pursuit to bring justice to the victims. Family members share their perspectives and personal stories regarding the victims and how the investigations unfolded. The series also spotlights law enforcement officers who work tirelessly in their quest to solve these horrific crimes.