When a young boy's legs are crushed after being pinned by a car, Malik is determined to use a revolutionary procedure using spider silk to save his limbs, while Zoe lobbies in favor of the safer route of amputation. Also, James, Walter and Talaikha care for Amelia (Laura Seay), a young woman in dire need of a liver transplant, but they're puzzled by her resistance when they tell her the donor is her estranged father, Simon (Doug Savant).

When a police officer suffers a brain injury in a car crash and can't remember who he is, James suggests a cutting-edge method to re-code the man’s brain to give him back the lost memories from his past and of his wife. Also, the team attempts to help an obese woman with the aid of an appetite suppression sensor, and Zoe tries to erase security footage of her kiss with Malik.

When James' beloved elementary school teacher is diagnosed with an aggressive cancer, he tries to employ a risky robotic surgery to save her, an approach with which Walter disagrees. Also, a military veteran blinded in combat and riddled with guilt refuses Zoe and Talikha's high-tech treatment that could restore his vision.