At the end of the 24th Century, and 14 years after his retirement from Starfleet, Jean-Luc Picard (Sir Patrick Stewart) is living a quiet life on his vineyard, Chateau Picard. When he is sought out by a mysterious young woman, Dahj (Isa Briones), in need of his help, he soon realizes she may have personal connections to his own past.

Picard begins investigating the mystery of Dahj as well as what her very existence means to the Federation. Without Starfleet's support, Picard is left leaning on others for help, including Dr. Agnes Jurati (Alison Pill) and an estranged former colleague, Raffi Musiker (Michelle Hurd). Meanwhile, hidden enemies are also interested in where Picard's search for the truth about Dahj will lead.

Completely unaware of her special nature, Soji captures the attention of the Borg cube research project's executive director. After rehashing past events with a reluctant Raffi, Picard seeks others willing to join his search for Bruce Maddox.

The crew's journey to Freecloud takes a detour when Picard orders a stop at the planet Vashti, where Picard and Raffi relocated Romulan refugees 14 years earlier. Upon arrival, Picard reunites with Elnor (Evan Evagora), a young Romulan he befriended during the relocation. Meanwhile, Narek continues his attempts to learn more about Soji while Narissa's impatience with his lack of progress grows.

Picard and the crew track Soji to the Borg cube in Romulan space, resurfacing haunting memories for Picard. Meanwhile, Narek believes he finally found a way to safely exploit Soji for information.