Someone is drawing mustaches on the great works of art at the Louvre Museum! Cousin Gaston needs the mice to help him find out who is responsible before the museum is closed and his friend Emily's father, the janitor at the Louvre, loses his job. At first, all clues lead to the artist, Monet, but soon our heroes discover it is Louis Moustache, a frustrated rat artist, who is defacing the paintings. Together they convince Louis to clean up his act (and the great works) and help him launch his own art opening for the mice elite of Paris.

The mice are visiting their cousin Agatha and looking forward to attending Queen Victoria's Golden Jubilee celebration, but there's trouble apaw when they discover that the diamond in the Queen's crown has been stolen! Agatha is afraid her best friend Molly's mum, the Queen's maid, will be accused of the theft. With a little help from Rathbone the Rat, a reformed safe cracker, the mice discover the thief is actually Maggie the Magpie who just can't keep her claws off of shiny objects!

The Mice are in Munich for the premiere of Strauss' newest symphony. Their cousin Otto, known far and wide as the Strauss Maus, leads the first run-through of the piece only to discover that the music has been switched for a cacophonous musical nightmare! Otto's friend, Strauss's son Franz, is convinced his father's assistant Herr Rauber is somehow responsible and has stolen his father's symphony! After following Rauber and running into some rats who plan to use the original manuscript as kindling for their fire, the mice retrieve the music just in time for the performance to begin.

The mice are about to witness the first air race from London to Paris! Actually, there are two races- one for mice- the other for humans. Their cousin Gaston plans to win the mouse race, while his friend Carole and her father hope to win the human one! But things are not going smoothly. When the pilot Carole's father has hired, Reginald Whimpley, takes their plane for a spin, the wheels fall off! Someone has sabotaged the plane! When Gaston takes his plane into the air, he almost crashes! Someone has sabotaged his plane as well! It is none other than Notail Nogoodnik, the nefarious dirty rat, who will stop at nothing to make sure he wins the rodent air race. Meanwhile, millionaire menace J.W. Howinger is busy sabotaging the human event. Gaston and the mice make sure both these villains are grounded for good!

The mice visit their cousin Ernestine and her friend Jeannie and discover that the famous cable cars are mysteriously breaking down. Jeannie's grandfather invented the cable cars, but her father, Jamie, can't figure out what is causing the problems. After a near crash, he fires Murphy, a brakeman with a bad attitude. Murphy disguises himself to look exactly like Jamie and proceeds to rob a bank. The police grab Jamie and charge him with the robbery. Meanwhile, the mice discover what's wrong with the cable cars. The rats are moving out - throwing their garbage everywhere and clogging the cable because there's an earthquake coming! (Rats are very sensitive to seismic activity.) The mice and Jeannie catch Murphy and deliver him to the police, while warning the townspeople of the coming earthquake.

The mice are in Corbett National Park in East India visiting their cousin Bajay and his friend Sarita. Sarita is very worried because animals have mysteriously been disappearing and she and her father, the park ranger, don't know why! Sarita is convinced that Sam McBean, who is new to the jungle, is somehow responsible for the disappearances. The mice meet a white tigress, Asura, who tells them (after scaring them half to death!) that her cub is missing. The mice find her cub and discover that the animals' watering hole has been poisoned. They also find the missing animals who have been caged by the evil McBean. In a daredevil rescue, Sarita, Asura and the mice save the animals and reveal McBean as a heartless animal poacher.