After an incident involving drugs and alcohol, high-flying Sydney heart surgeon Hugh Knight is banned from surgery and forced to work as a GP in his rural hometown of Whyhope. Upon returning, he reconnects with his brother, Matt, who is now married to his ex-girlfriend, Charlie.

After a drug-fueled night of partying together, Hugh and his colleague Aoife are called out to a remote farm to help a man trapped under a tractor. Hugh tries to help his sick friend Joey, while Hugh’s mother, Meryl, calls a family dinner with ulterior motives.

Hugh is concerned about his father’s health, but Jim remains as distant and uncooperative as ever. Trevor, Hugh’s colleague from Sydney and co-pioneer in artificial heart research, arrives with a new prototype, and the two plot an unusual way of testing it.

Hugh travels back to Sydney to face a lawsuit because of a recording a patient took during surgery. Charlie struggles with the possibility of infertility, and her frustration is compounded when Matt decides to accompany Hugh to the city at the last minute.

When Hugh risks life and limb to help an injured soccer player stuck in the middle of a live minefield, the town calls him a hero. Meanwhile, Penny and her son face the anniversary of her husband’s death.

When a patient goes brain-dead after a fight, a team from Sydney arrives to collect the man’s organs for donation. Fearing that the city doctors will see him in exile, Hugh hides in embarrassment. Charlie and Matt deal with the aftermath of their ectopic pregnancy.