A young and hungry Irving Lorenzo uses his drive and ambition to shake up the record industry, helping to establish the careers of Jay-Z, DMX, & Ja Rule, and others, which ultimately lead to him forming his own label under Def.

Murder Inc. Records rises to the top of the music industry through Irv Gotti's hit-making abilities, striking gold with hit records for Ja Rule; the label begins turning Ashanti into a superstar.

Irv Gotti falls in love with new artist Ashanti, who propels Murder Inc to Guinness Record sales; Irv attempts to sign Nas, and 50 Cent sways fan support with his attacks.

The FBI comes for Murder Inc and Irv Gotti's notorious friend Kenneth Supreme McGriff, making prison inevitable; while artists depart, Irv tries to recover with a new artist and name.

Murder Inc and hip hop itself are on trial as Irv Gotti fights for his freedom, his legacy, and a chance to make a multimedia comeback while he reckons with relationships lost along the way.