The Venture family visits Tijuana, Mexico, where the boys are kidnapped by the Monarch, Brock is buried alive, H.E.L.P.eR. gets a south-of-the-border makeover and Dr. Venture's kidneys are stolen. The Monarch's moving and powerful origin is also revealed.

The Venture family must travel to space to repair an orbiting space station that Dr. Venture's father built in the 1970s, but a mysterious space phantom could be haunting the station and Brock's presence adds heat to an already tense romantic relationship between the station's two officers.

To protect the Venture compound while Brock is on his yearly mountain survival sabbatical, Dr. Venture builds a panic room and a robotic bodyguard -- which are soon put to the test when both the Monarch's and Baron Ünderbheit's henchmen choose the same night to launch separate attacks. While the supervillains bicker, over who has dibs on the head of Dr. Venture, Brock is busy befriending the strangest couple in the Cascadian mountains. Oh yeah, and H.E.L.P.eR. runs away in a fit of jealousy.

Dr. Venture is offered a job by theme park owner and cartoon magnate Roy Brisby, who won't take no for an answer in his quest for worldwide entertainment dominance. Meanwhile, the boys are kidnapped and given the Patty Hearst treatment by Orange County Liberation Front, a group of militant suburbanites who want to take down Brisby's empire to save their neighborhood. Brock enlists the aid of former lover and fellow superspy Molotov Cocktease to rescue the family, but she may have her own fiendish agenda.

Dr. Venture's new invention keeps sucking the family in -- literally -- but the Venture's strange new neighbor -- master of mysticism Dr. Orpheus -- could hold the secret to their escape. And his teenage daughter may hold the secret to Dean's heart.

On a scientific expedition in the Bermuda Triangle, Doc's experimental equipment awakens and possibly enrages the submerged ghost of Major Tom, a test pilot who crashed in an experimental aircraft designed by Doc's father., the Ventures' hydrofoil is hijacked by a group of fake ghost pirates who've been stranded in the Sargassum since Jesus Jones was popular.