Set in Aruba and Fallbrook, CA. Beth Holloway shares her journey to find answers about her missing daughter Natalee and begins her quest to help families with loved ones who have vanished without a trace. The episode also introduces California family of four, the McStays, who all suddenly vanished without a trace.

Set in Homosassa, FL and Ocilla, GA. Viewers meet the family of a 10-year-old girl who went missing from her Florida home and her father embarks on a journey to clear his family name and bring a killer to justice. Additionally, Beth visits the loved ones of a high school teacher and former beauty queen who vanished from her home late one night.

Set in Curacao. Beth investigates a case where a young woman vanishes off the deck of a cruise ship. In their search for answers, her parents stumble across what appears to be an international sex slave operation.

Set in Orlando and Welch, OK. Beth investigates a case in which a 24-year-old warned her father of a suspicious character and the worst is assumed when she goes missing and only her abandoned car is found. The episode also takes a look at a case in which authorities realize a tragic fire was no accident after two people are found murdered and two teenage girls involved go missing.

Set in Philadelphia and Leesburg, FL. Beth looks into a case in which a young pregnant woman vanishes from the streets of Philadelphia and the City of Brotherly Love comes together to bring her captor to justice. The second case involves a toddler's abduction which galvanizes a community.

Set in Belton, MO and Chicago. Beth talks to the family of a teen who left for school one day, never to return home. The mystery deepens when investigators learn a missing persons report was filed days before her actual disappearance. The series also follows the story of a young man who vanished without a trace while on a school trip to Chicago.