Susan's old friend Barbara, needs to get 20 alpacas from her farm in Oregon to her son's new farm in Washington. The Denickers fall behind schedule witnessing the birth of an alpaca and helping shear the fleece from a few of the unruly ones.

The Denickers must transport a rare lizard that's armed with razor sharp claws, lethal teeth, and a whip-like tail, proving to be a risky job. The gang get a call from the to drive 13 rescue dogs from West Virginia to a shelter in Salem, Mass.

The team helps a rescue center relocate and release 100 rehabilitated ducks, geese and swans into the wild. Susan and Anthony deal with an emotional farewell as they help move three black bears to a sanctuary where they'll have access to more land.