One of the most popular comic book superheroes of all time makes his leap to the big screen in Spider-Man, which already has wrapped up a collection of shattered box office records in its web. When student Peter Parker (Tobey Maguire) is bitten by a genetically altered spider, he gains superhuman strength and the ability to cling to any surface. Meanwhile, megalomaniacal businessman Norman Osborn (Willem Dafoe) is undergoing some changes of his own. An experimental formula has gone awry, increasing his intelligence and strength but also driving him insane. He is now the Green Goblin, Spider-Man's arch-enemy, who will put to the ultimate test young Peter Parker's vow to use his abilities to fight crime and help innocent people.