In 2020, Louis de Pointe du Lac tells his story to journalist Daniel Molloy. In 1910, Louis lives in New Orleans as executor-in-charge of his family's fortune, but when he meets the vampire Lestat, Louis' life begins to unravel in otherworldly ways.

Beginning his life as a vampire, Louis learns the rules of vampirism from his maker and companion, Lestat, but finds he is not as remorseless as his mentor; in Dubai, Louis reveals more of his modern-day vampire lifestyle to Molloy.

Louis' relationship with Lestat is tested; after the growing racial tensions in New Orleans reach a boiling point and threaten the future of Azalea Hall, Louis makes a choice.

Claudia's transformation into a vampire completely changes Louis and Lestat's lives. As Claudia asks more questions, Louis and Lestat confront questions about making a teen vampire. Claudia learns the dark realities of her new life.

Claudia leaves home for a college sojourn and to learn more about vampires, but tensions in the family come to a boiling point when she returns; Louis and Lestat receive surprising news from Louis' sister.

The vampire family attempt to reconcile, but Louis and Claudia soon doubt Lestat's promises; in Dubai, Molloy has a shocking realisation.