When physics student Quinn invents a way to travel to parallel universes, he takes his friends Wade and Maxmillian along for the ride. But they accidentally pick up another passenger along the way.

The sliders witness an epidemic taking its toll on the population when they wind up on Earth in a time before antibiotics have been discovered.

The sliders land on an Earth in jeopardy, and must find a solution to the chaos when they learn a meteor is on its way.

In pre-Revolution United States, the sliders come face to face with Arturo's double: a sheriff who is planning a royal assassination.

Rembrandt and Wade are mistaken for gods when they wind up on an Earth in a time when the Summer of Love never ended and free love remains.

The Sliders find themselves on an Earth where being intelligent is held in a higher regard than being a famous athlete.