A housewife living a perfect life on the Upper West Side in the 1950s discovers a previously unknown talent.

Joel leaving causes Midge's life to go into a tailspin; Midge and Joel's parents butt heads while trying to keep the family together; Susie pushes Midge to get back on stage and find her voice.

Midge finds herself in legal trouble following another arrest, forcing her to rely on Susie's street smarts; Abe approaches Moishe with an interesting proposition; Lenny Bruce offers unconventional inspiration for Midge's act.

Midge starts to move on from her once-perfect life; Susie shows Midge the ropes while going on a tour of New York comedy clubs; Rose takes too much pleasure in Midge's new living arrangements.

Midge dives into a new line of work and makes quirky friends along the way; Susie continues her quest to keep Midge's career moving forward, but she gets hit with some setbacks; Midge and Joel experience the negatives of their new lifestyles.

Midge finds a different kind of audience to perform for; Abe gets offered the experience of a lifetime; the Weissmans come together for a family dinner; Susie shows off her management skills.