Despite having a successful career as a skilled obstetrician/ gynaecologist, Mindy Lahiri is unlucky in love and desperately needs to get her personal life back on track before her friends and colleagues are forced to stage an intervention. In this first episode, Mindy makes a drunken toast at her ex-boyfriend's wedding, and resolves to turn her life around.

Mindy is put in charge of recruiting a new nurse, and offers the job to a reformed ex-prisoner. Jeremy employs his talent for ending relationships when he has to fire a rude and inefficient health-care professional, and Mindy plans a date with a cute guy she meets in a bookshop.

During a staff outing to a trendy nightclub organised by Shauna, Mindy meets a handsome lawyer who represents the New York Knicks basketball team.

Mindy frantically searches for the right costume to impress Josh when he invites her to a prestigious Halloween party. An embarrassed Danny and Jeremy both sneak out of work early to take their driving tests. Meanwhile, Mindy bumps into her ex-boyfriend Tom and ends up confiding in him about Josh.

Mindy asks Danny to be her new gynaecologist, but as the time for her first physical examination approaches, neither of them will admit that they feel too uncomfortable to go ahead with the appointment. Meanwhile, Jeremy wants to retrieve his expensive watch from Mindy's flat, but he needs help from Morgan and Betsy to break in and get it.

While Josh is out of town on a trip, Mindy and Morgan cook Thanksgiving dinner at Gwen's house. Mindy is surprised to find that the guest list includes her former blind date, Dennis, who turns up with his new girlfriend. Danny is looking forward to spending the holiday alone at the office, while Jeremy meets Betsy's eccentric family for their seasonal gathering.