When flight attendant Cassie Bowden meets passenger Alex Sokolov, she decides to spend an extravagant, very drunk night with him. But when she wakes up next morning beside a dead body - and with no memory of what happened - Cassie fights to keep her wits about her long enough to make it back to New York, where more trouble looms.

Rattled by her own lies and under pressure from the FBI, Cassie goes against her lawyer best friend Annie’s advice to lay low and tries to track down Alex’s mysterious business associate Miranda – with bizarre and shocking results. After an unsettling meeting with Agents Hammond and White, Cassie meets the easy-going Buckley on a night out to forget her troubles.

Upon landing in Rome, Cassie deals with her sudden feelings of loss, and Megan confesses that she has secrets of her own. Back in New York, Cassie doubles down on finding Miranda by unceremoniously crashing Alex’s memorial service. Searching for intel on the Sokolovs, Annie ambushes Alex’s former colleague Sabrina and calls in a favor with a client.

After piecing together evidence with help from Annie’s not-boyfriend Max, Cassie follows the paper trail to a suspiciously empty private jet manned by Nate, her on-again, off-again flight crew fling. Meanwhile, Megan attempts to hide her shady dealings from her family, and Annie faces a reprimand from her boss, Diana. Later, a visit from her brother Davey and his family forces Cassie to confront her memories of her “unconventional” childhood.

With Miranda on her tail and the FBI closing in, Cassie enlists Max in a plan that involves breaking and entering, computer fraud, and too much vodka. Meanwhile, Annie is forced to repay an ominous favor to a client, and Megan’s secrets threaten to come to light.

Reeling from a major fallout with Annie – and running from anything related to Alex – Cassie brings Buckley along for an alcohol-fueled escapade that ends in a meltdown. Meanwhile, Megan embarks on a clandestine mission, and, amid mounting pressure from her co-conspirators, Miranda continues to hunt Cassie down.