It's a matter of life or death. When a new patient is in desperate need of a heart transplant, we are introduced to the life of world renowned heart transplant surgeon Dr. Alexandra Panttiere (Melissa George). There is nothing conventional about Alex. She is as cutting edge and unorthodox in the OR as she is with the two men in her life. Her approach to medicine is without boundaries, as is her approach to everything else in her world, which is always full of surprises.

An ethical debate arises when Alex suggests performing risky surgery on conjoined twins diagnosed with cancer; Alex questions her relationship with Pierce.

Alex sees a young man who is only able to recite sentences backward as an opportunity to test some new technology, but Millicent disagrees.

Alex makes a risky move when she tries to find volunteers for an experimental cancer treatment; Max wants to change the family dynamic with Alex; Ji-Sung and Callahan connect.

A patient questions Alex's ability to leave personal grief outside the OR when she performs heart surgery on the anniversary of her sister's death; Millicent dates an artist; Pierce wants to be more of a part of Alex's family.

Alex, Jesse and Millicent fight to save a former heart transplant patient when she sustains life-threatening injuries in a car crash.