Mindy Lahiri is a successful doctor, but when she leaves the office, all bets are off. She wants to become a more well-rounded woman, someone who is punctual, frugal and well-read instead of someone who is obsessed with romantic comedies and likely to give an inappropriate toast at a wedding. Not the least of Mindy's obstacles are the doctors she shares her OB/GYN practice with - especially self-absorbed Jeremy, who seems to keep turning up in Mindy's bed, despite her best efforts to resist. Mindy finds support on her quest for growth from Gwen, her best friend from college.