When the E.D. is flooded with patients from a crash, the entire team is pulled in to help; Charles can't shake the feeling that he knows the new E.D. attending; Archer has second thoughts on the eve of his kidney transplant.
Dr Rhodes is tasked with delivering some devastating news. April suffers an accident and Dr Halstead presses her into seeking treatment.
A young cancer patient struggles to tell her parents about her condition. Dr Reese turns to Dr Charles and Detective Lindsay for help with a troubled young man. Meanwhile, a teen science geek and her friends impress Dr Choi and Natalie.
A mass shooting at a cinema inundates the hospital with gunshot victims, including the shooter. Dr Rhodes faces a crisis of conscience.
After a baby is abducted from the hospital, Goodwin enlists the help of Dr. Charles and Dr. Reese to find the suspect. Due to the lock down, Dr Rhodes must find a way to get into the operating room to help perform open-heart surgery.