Louis de Pointe du Lac lives in 1910 New Orleans as executor-in-charge of his family's fortune; when he meets the vampire Lestat, Louis' life begins to unravel in otherworldly ways; in 2020, Louis tells his story to journalist Daniel Molloy.

Beginning his life as a vampire, Louis learns the rules of vampirism from his maker and companion Lestat; Louis discovers increasing differences between himself and Lestat; in Dubai, Louis reveals more of his modern-day vampire lifestyle to Molloy.

Louis continues his life as a businessman of Storyville; when an old friend comes to town, Louis's relationship with Lestat is tested; Louis' business intertwines with growing tensions in New Orleans, leading to a new chapter in Louis' vampire life.

Claudia's transformation into a vampire teen completely changes Louis and Lestat's lives; as Claudia asks more questions, Louis and Lestat are forced to confront questions about making a teen vampire; Claudia learns dark realities of her new life.

Claudia leaves home for a college sojourn and to learn more about vampires; Louis and Lestat live through the Depression and received surprising news from Louis' sister; tensions in the family come to a boiling point when Claudia returns.

The vampire family attempt to reconcile, but Louis and Claudia soon doubt Lestat's promises. In Dubai, Molloy has a shocking realisation.