Jackpot Airlines is a budget carrier whose junket flight from Los Angeles to Las Vegas and back is filled with dreamers hoping to finally make that big score. Long-suffering flight attendant Ronnie holds things together in the cabin, managing the revolving door of bachelor parties and 21st birthdays, and developing a location-based relationship with Colin, an economics professor who is a frequent passenger on her flights. Theirs isn't the only relationship fostered by proximity. Together, with the rest of the crew and regulars, they are part of an unconventional family from Friday to Sunday, whether they like it or not.