Most Extreme Humans

Mark's hands are 20 times bigger than a normal adult male's; after learning that his condition may require amputation, Mark stopped seeing doctors; now troubling changes to his hands mean he must go back.

Winner of Uganda's Ugliest Man contest, Godfrey has a rare disorder that has left him disfigured. With 10 children, a new baby on the way, and his condition worsening, he is seeking medical answers that will determine his future.

Life defined by height: in Turkey, the world's tallest woman lives with an unknown genetic condition linked to extreme growth and fragile bones, while in Brazil, the world's shortest couple navigate dwarfism and its physical challenges.

Milagros lives with tumours so heavy that her face droops down to her torso.

In rural Indian, Lalit's face and body have been thickly covered in hair since the day he was born; doctors theorised that the hair would fall out once he reached peak maturity; Lalit seeks out a specialist to learn his fate.

Mahfuza and Nelly are living with Harlequin ichthyosis, one of the world's rarest and most severe skin conditions. Mahfuza prepares for her first boxing match. Nelly fully supports her friend but worries that the high risks may outweigh the rewards.