Richmond Trinity Hospital's chief nursing officer Christina Hawthorne tries to stop an end-stage cancer patient's attempt at suicide.

Richmond Trinity has closed its doors, and now many of the staff have been shifted to James River, a rundown hospital in a low-income area. Things are made even worse when Christina and Bobbie have a run-in with the ER nursing supervisor. Tom gives up his administrative duties and dives into direct care.

On the heels of her and Tom’s (Michael Vartan) wedding, an attack in the hospital parking lot endangers both Christina (Jada Pinkett Smith) and her unborn child. And as Morrissey (James Morrison) looks to appoint a new head nurse, Steve (Adam Rayner) makes an important decision about his future.