Yuri is in town, all dressed up for a date, when a dying agent from the 3WA (World, Welfare, and Works Agency) hands her a special card to give to headquarters. Yuri is reluctant to take it until some guys in blue uniforms arrive and chase her down. She passes the card to her reluctant partner Kei, but somehow the blue uniform guys grab it. Kei and Yuri go after the guys, but also have to evade them when the girls secure the card, and they end up having to go through some bad sections of town, leaving a wake of destruction along the way.

Kei and Yuri are at an airport, escorting some guys to a plane, but the guys get shot. The girls pursue the assassin, who turns out to be a beautiful and very skilled woman named Lady Flair. After failing to capture her, they notice that she has been apprehended by the Military Police. But Kei doesn't buy that idea, and they storm the military base later, where they are developing giant spider-like robots.

After spotting bigwig Waldess at his GCN corporation, Kei tries to confront him but the bodyguards apprehend her and toss her out. Frustrated, Kei has had enough, and resigns. Yuri is assigned to protect a neuroscientist, but runs into trouble as Lady Flair storms in to kill him. Waldess takes a sabbatical on a cruiser ship on an ocean full of deadly whirlpools. Kei pursues her but gets into trouble as Lady Flair is aboard the ship, and Yuri pursues to try to help out.

Professor Kupps has made it to 3WA headquarters and has hidden himself in a virtual reality role-playing world of his own creation. It'll be up to Yuri to go in there and save him. Kei leaves headquarters but notices the blue uniformed men from the first episode on the subway; they are plotting to attack 3WA and kill Kupps. As Yuri enters a stronghold and fights fantasy monsters in the virtual realm, Kei gets dragged into 3WA headquarters.

With Kaps's testimony, the GCN is being investigated. The guys that represent Lucifer decide that Waldess is too dangerous, especially when he's still going after Siren, so they hire an assassin who is none other than Lady Flair! Kei gets her gun repaired but the 3WA confiscates it. Meanwhile, Yuri gets a new ditzy partner named Lilly, and they have to help Unit 9 stake out Waldess at a spaceport, but trouble arises when other assassins make their move against Waldess.

Waldess has infiltrated the Siren space station! As he takes over broadcasts and declares his conquest of the galaxy, Yuri and Lilly are sent with the 3WA to fight him. But Lilly decides to quit in the middle of the mission, leaving Yuri alone. Kei must make a decision on the future of the Lovely Angels, while Lady Flair confronts her past.