The staff of Gaffney Chicago Medical Centre's new ER are given a baptism of fire when the department's opening is interrupted by a train crash.
Dr Choi treats a teenage mother who abandoned her newborn baby in an alley. The nurses surprise Dr Manning with a baby shower.
Dr Connor Rhodes must deal with his past when he takes care of a family friend; Dr Halstead struggles with a surgery that could impact a young musician's hearing.
A mass shooting at a cinema inundates the hospital with gunshot victims, including the shooter. Dr Rhodes faces a crisis of conscience.
Rhodes and Zanetti race to save a member of Firehouse 51, April's brother struggles during his first day at the hospital, and a woman saved from a burning building leads to a bigger mystery.
Dr Rhodes tends to two injured airplane stowaways, but their treatment becomes complicated when the Department of Homeland Security arrives.
Dr. Daniel Charles
S. Epatha Merkerson
Dr. Will Halstead
Nurse April Sexton
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