Gabriel has a huge growth on his clavicle but is terrified of surgery; Karen has dealt with painful, scaly feet for 22 years with no diagnosis; Lorne has embarrassing tumors on his face and body and believes this is why he hasn't met the one yet.

Ruben is a personal trainer whose head growth has prevented him from seeing clients; Kaitlin has blue marks and scars up and down her arms due to long-term drug use; Adrian was left with a disfiguring bump on her behind after falling down stairs.

Margarita is a matriarch who has been hiding her armpit lump from her family; Kayla is an aspiring musician with a promising career that her painful eczema has brought to a halt; Bradley has a concerning growth that looks like raw meat on his leg.

Jeremy is a pastor with a hanging growth in an embarrassing location; Evelyn has recurring keloids that have been removed three times and come back bigger each time; Todd has a bump protruding from his forehead.

Tameru is a drag queen, but he has a myriad of cysts that are the real drag; Devon has uneven skin she thinks may be the result of a hysterectomy a decade ago; Amy has large growths all over her head that make her look like a "hot mess."

Jason lost their confidence and motivation due to the large growth on his neck; Shawnell's multiple mystery bumps on her head destroy her self-esteem; Jim's growth protruding off of his nose makes it hard to breathe.