Harley Quinn has finally broken things off with the Joker and tries to make it on her own as Gotham City's criminal queenpin; with the help of a ragtag crew of DC castoffs, she tries to get a seat at the biggest table in villainy, the Legion of Doom.

Harley tries to make a big splash by crashing one of the Legion of Doom's criminal enterprises with the help of her bestfriend, Poison Ivy.

Realizing that she needs a crew to pull of legit heists that will attract the Legion of Doom's attention, Harley tries to recruit disgraced "Wonder Woman" villain Dr. Psycho and Clayface, Gotham's shapeshifting thespian extraordinaire.

Now that she has a crew -- including new member King Shark -- up-and-coming supervillain Harley Quinn needs a nemesis; while she goes after Gotham's big fish, Batman, she ends up with an adolescent Robin, making her a laughingstock of the underworld.

While trying to find a lair to house her crew, Harley suffers a paralyzing identity crisis; with the help of Dr. Psycho's telepathic powers, the crew must enter Harley's mind to free her from her paralysis.

During a heist gone wrong -- thanks to Harley's impetuousness -- Clayface loses an arm, which turns out to be evidence to enterprising GCPD commissioner Jim Gordon and a key witness against Harley and her crew.