Pinky (series star Rob Paulsen) and The Brain (series star Maurice LaMarche) go undersea in a submarine to find the key ingredient for a hypnotic pancake batter.

The Brain schemes to collect workmen's compensation to fund another plan to take over the world in "Of Mouse and Man."

In "Tokyo Grows," during the 1950s, The Brain creates monsters to scare Tokyo and then rescue it. Later, in "That Smarts," The Brain decides that the key to his success is to make Pinky as smart as he is. Finally, in "Brainstem!" Pinky and The Brain sing about the parts of the brain.

In the 1930s, The Brain poses as The Fog and plans to broadcast his hypnotic voice over the radio in "Pinky and the Fog." Then, Pinky and The Brain alter the inscription on a space probe to go "Where No Mouse Has Gone Before." Later, in "Cheese Roll Call," Pinky sings about cheeses.

Pinky and The Brain establish a bogus country, "Brainania," in order to receive aid from the United States.

In "TV or NoT TV," The Brain tries to take over the world by starring in a hit TV sitcom.