While on Air Force One, a Navy Commander dies. Agents from NCIS decide to take the investigation into their own hands and also force Secret Service Agent Kate Todd to help.
The investigation of the shooting of Holly Gribbs continues, while Grissom and Stokes examine the murder of a Las Vegas mega-winner.
The Jeffersonian team investigates the death of a young boy whose soul remains very much alive. When psychic Avalon Harmonia (guest star Lauper) attempts to help the deceased’s spirit cross over, each member of the team begins to question his or her own beliefs about life after death.
When Goodwin (S. Epatha Merkerson) receives financial complaints from the hospital board, she is forced to implement new guidelines that cause headaches for the doctors. Dr. Rhodes (Colin Donnell) and Ava (Norma Kuhling) continue to compete in the operating room, while Dr. Charles (Oliver Platt) and Dr. Reese (Rachel DiPillo) are surprised when they treat a man who has a peculiar theory about his sickness. Dr. Manning (Torrey DeVitto) and Dr. Choi (Brain Tee) can't figure out what is wrong with a young girl, leading them to look to a questionable source for answers.
Masters faces a career crossroads on her last day as a medical student and struggles with the choice to continue on the path to become a surgeon or to accept the rare opportunity to join House's team officially. Meanwhile, the team treats a 16-year-old girl who inexplicably collapsed days before embarking on an ambitious sailing tour around the globe. Despite the patient's life-changing diagnosis, the patient's family insists on getting her back on the seas in time for her potentially record-breaking launch. But to the team's surprise, including House, Masters makes a bold decision regarding the patient's treatment.
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