Michael and Sara realize that Warden Pope (guest star Stacy Keach) is the key to recovering information that will bring down "The Company"; Mahone corners another escapee; C-Note fears for his daughter's life; Sucre learns the dangers of hitchhiking en route to reuniting with Maricruz; and T-Bag walks down memory lane when he takes the Hollander family to his childhood home.
A current murder case leads Rush and Valens to reopen a cold case from 1992 involving a young woman, Vanessa Prosser, killed after leaving a political event on election night.
When a man stumbles into Magic City Lab requesting to pay in advance for his own autopsy, the team is confused and skeptical – until that same man turns up dead the very next day.
As the FBI tries to prove that a corrupt construction company is to blame because they have been burying containers of toxic waste under school playgrounds, they discover that the students in the school have a higher rate of cancer and neurological problems. Charlie tries to mathematically prove cause and effect between the pavement materials and the cancer clusters. Meanwhile, Millie, Charlie's new boss at Cal Sci, orders him to spend less time helping out the FBI and more time in their department.
As Shane enlists Vic and his men in the search for the body of a teenaged informant, the disappearance of two cops on patrol begins to look like payback for Monica's tough new policies.
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