After the disappearance of his daughter is ignored by local police, a Native American man decides to take matters into his own hands. When his search escalates to murder, the team must track him down before his crusade claims any more lives, on FBI: MOST WANTED.
Mary and Marshall try to help FBI Agent Mike Faber convince his informant to enter Witsec. Despite their best efforts, the informant refuses their protection and gets himself into a heap of trouble. Meanwhile, Stan has to deal with an ex-boxer/witness suffering from pugilistic dementia. Guest starring Steven Weber.
A downtown gas explosion sends dozens of casualties to the hospital. TC, Drew and Gwen scramble to the chaotic scene as Topher leads the team at the hospital. Meanwhile, Paul delves into his first night in surgery rotation while dealing with the unexpected arrival of his neurosurgeon father.
Cheryl, Heather and Cal get jobs as they try to embrace a crime-free lifestyle; Cal finds out his new job as a pool boy has unexpected requirements.
As Jordan (Jill Flint) faces suspension for ignoring a religious patient’s “do not treat” directive, a military training accident makes Drew (Brendan Fehr) directly responsible for a fellow soldier’s life.