100 HUMANS features social experiments that seeks answers to some of life's pressing questions. Hosts Zainab Johnson, Sammy Obeid, and Alie Ward conduct experiments on 100 adult human volunteers from all walks of life to examine human behavior. It seeks to learn more about things like whether being funny makes you sexier, and why older groups of people are more successful at certain things than younger ones. Interviews with scientists and other experts offer insight into some of the theories being tested, and explain some of the results.