When intrepid astronaut John Crichton (Ben Browder) blasts off from Earth aboard the experimental spaceship Farscape One, he accidentally falls through a wormhole and emerges on the far side of the universe, right in the middle of an interplanetary conflict. His own ship destroyed, Crichton finds refuge aboard an enormous living spaceship named Moya, which is crewed by an eclectic band of galactic rogues. Many of his new colleagues are just as displaced as the lost astronaut, and Farscape follows their adventures as they try to return to their various home planets.