When Hope Zion Hospital's Chief of Surgery ends up in a coma, he finds himself wandering the halls in spirit form. Stuck between worlds, he watches as his fiancée and the staff of the hospital fight to keep patients – and hope – alive.

Alex treats a young boy with mysterious symptoms while dealing with the arrival of Charlie's ex-wife. Elsewhere in the hospital, Joel and Maggie try to help a patient who refuses life-saving treatment on religious grounds.

After Charlie's hand moved in the last episode, Alex has high hopes for his recovery, while she treats a patient who already has multiple surgeries under his belt. Meanwhile, Charlie coaches a young man killed in a roofing accident who has unfinished business with his severely injured brother.

A sleep-deprived Alex takes on a night shift in the ER where an all-star hockey enforcer may be skating full-speed towards an early death. Meanwhile, Charlie meets a suburban punk who is facing the biggest fight of his life.

A high profile double hand replantation becomes Alex's chance to prove to Kinney that she is still capable of being Chief Surgical Resident. In the ICU, Maggie believes a homeless man may have been misdiagnosed.

When a severely injured man under the spell of hypnosis cannot remember his identity, the hypnotist who put him under is called into the hospital – where he uses his psychic ability to connect Charlie and Alex. Meanwhile, a young woman comes into the E.R. with a neck injury, but it’s Hope Zee’s psych resident, Gavin who knows how to help her.