A Suitable Doner centers on a disgraced, 75-year-old ex-sheriff, whose life ends at the hands of corrupt cops, but then is brought back to life – by a pair of young tech scientists – and given a second chance as a 35-year-old with unpredictable near-superhuman abilities.

Due to the power surge that Mary and Otto caused in bringing Pritchard back to life, two notorious murderers escape from prison. Still determined that this is his city to protect, Pritchard goes on the hunt for them, and Mary – who believes she’s partially responsible for the fugitives’ escape – offers assistance. Meanwhile, in order to win Duval’s trust, Pritchard tells him they’re half-brothers.

Pritchard tries to prove to Duval that he was a better police officer and man than his son ever knew. Meanwhile, he and Duval go up against a deadly psycho and another father-son duo that is out to cause trouble.

A case from the past comes back into play as Pritchard and Duval investigate a series of murders involving young prodigies. As the investigation unravels, Duval comes to terms with the possibility that Pritchard could be his father reincarnated. Meanwhile, Pritchard manages to become a confidential informant for the FBI.

Mary’s life is in danger when a dead pool predicts her death for the same day as an important Lookinglass product launch. Meanwhile, when Pritchard is needed the most, he fails to show up and winds up in the hospital after a near fatal brawl. After Pritchard's hospitalization, Otto begins to find glitches in Pritchard’s code that might not only drastically change Pritchard, but Mary, as well.

Pritchard and Duval must stop a killer who mutilates and disfigures his victims. Meanwhile, as Pritchard and Mary grow increasingly close to one another, Otto feels resentment and wants to find a new donor.