When a young Arizona businessman is found slaughtered in his bathroom, friends point police towards his on-again off-again ex-girlfriend. Facing the death penalty, Jodi Arias takes the stand for an unprecedented 18-days in an attempt to explain how the brutal killing of her ex-boyfriend was self-defense.

When an off-duty Dallas police officer shoots a man in his own apartment, the jury will have to decide if it was murder or a tragic mistake. Amber Guyger takes the stand in her own defense to convince the jury not to lock her away for up to 99 years.

When a parolee is bounced from his job, he seeks retribution on a peaceful, unwitting community when he kidnaps, tortures and kills a mother and caregiver. Scott Nelson takes the stand to give a convoluted explanation on why he blames his parole officer for his seemingly random decision to kidnap, torture and kill a local Florida woman.

Shayna Hubers takes the stand to defend herself after she brutally murdered her on-again, off-again boyfriend, Ryan Poston. She willingly takes the stand to prove her actions were in self-defense, by showing Ryan's abusive side.

A shootout with police in West Virginia leads to the arrest of a 23-year-old Texas man, who is charged with savagely killing an elderly couple, robbing them and burning down their home. Facing the death penalty, the defendant decides to take the stand and points the finger at the surprising suspect he claims committed the horrific crimes.

Former Houston doctor Leon Jacob is currently serving a life sentence. He was found guilty of plotting, along with his girlfriend, Valerie McDaniel, the murder of his ex-girlfriend and Valerie's ex-husband. Valerie took her own life after serving some time in prison. Leon Jacob takes the stand to defend his rocky past.