In the series premiere episode, acting coach Sandy Kominsky must face fears of his own mortality, while being there for his longtime friend and agent, Norman, whose wife, Eileen (recurring guest star SUSAN SULLIVAN) is terminally ill.

Following Eileen's passing, Sandy must immediately begin making good on his promise to take care of Norman and help him plan for her very specific funeral.

Sandy deals with a health scare, while Norman's mourning process is complicated by the presence of his estranged, drug-addicted daughter, Phoebe (recurring guest star LISA EDELSTEIN).

Anxiously awaiting the results of a biopsy, Sandy tries to prove that he's still young, while Norman's patience is tested living with his new housemate, his addict daughter Phoebe.

The results of Sandy's biopsy prompt him to take his relationship with Lisa (NANCY TRAVIS) to the next level, while Norman goes back to work in an attempt to move on with his life after Eileen.

Sandy and Norman hit the road to drop Phoebe off at rehab in Arizona. After dropping her off, Norman questions what he has left to live for. Meanwhile, Mindy discovers Sandy hasn't paid taxes in years, putting the future of his acting school in jeopardy.