Just like the video game series from which it was inspired, The Super Mario Bros. Super Show features the antics of a pair of Italian brothers, Mario (Captain Lou Albano) and Luigi (Danny Wells). In live-action segments, the brothers play host to a series of famous guest stars having plumbing problems: Cyndi Lauper, Vanna White, Eve Plumb. Between the live-action segments that bookend each show, animated versions of Mario and Luigi go on wacky adventures, often satirizing a then-current movie, such as when Mario and Luigi end up in a Butch Cassidy and the Sundance Kid Old West town, or Two Plumbers and a Baby (Three Men and a Baby). In the animated segments, the brothers are often rescuing Princess Toadstool, a gentle royal constantly kidnapped by reptilian villain King Koopa and his evil henchmen.