Watson is a medical show with a strong investigative spine, featuring a modern version of one of history's greatest detectives as he turns his attention from solving crimes to solving medical mysteries.

Watson and the fellows investigate the perplexing case of a family man with a bullet lodged in his head who insists he is a Scottish soldier and seems to be hiding something nefarious.

Watson and the fellows treat a comedian who collapses at an open mic night, but throughout the case her past is revealed to be much more complex than initially believed.

When Sasha discovers a link between her current patient, who has advanced cancers and distinctive lesions on his tongue indicative of Cowden syndrome, and a cadaver she dissected during medical school, the team traces the case to Amish country.

Watson takes a major ethical risk when he decides to treat a sickle cell patient with an unorthodox surgery, and the team faces their own dilemma when they must decide whether to look the other way or help the young woman.

Stephens musters the courage to ask Watson to help him when his camgirl suddenly collapses during a video call. He does not know anything about her real life, so the team must act quickly to locate her before it's too late.