A young autistic surgeon (Freddie Highmore) who relocates from Wyoming to California to complete his medical training relies on his top-notch skills to disprove his colleagues’ skepticism.

When prejudices about his autism force Shaun (Freddie Highmore) to sit on the sidelines at St. Bonaventure, his colleagues don’t hesitate to claim credit for his ideas.

As Shaun (Freddie Highmore) and Claire (Antonia Thomas) improvise to preserve a liver for a transplant, Andrews (Hill Harper) is pressured to partner with Melendez (Nicholas Gonzalez) on a wealthy patient’s routine surgery.

Melendez (Nicholas Gonzalez) takes a risk to save a mother and her unborn child, placing the hospital in legal jeopardy. As Shaun (Freddie Highmore) struggles to adjust to his new life, he and Claire (Antonia Thomas) team up to treat a teenage porn actress.

After bonding with a young patient, Shaun suspects that he’s been misdiagnosed with a fatal form of brain cancer. An elderly patient’s allergic reaction exposes a longstanding rift with his son.

Shaun and Claire devise an experimental procedure capable of saving a young groom's leg and life, but the patient's loved ones must learn to work together. Meanwhile, Jared struggles to connect with a patient whose scars may prove too deep to overcome.