The International Response Team investigate when three American volunteers go missing in Bangkok. Cultural anthropologist Clara Seger helps gather evidence before a storm washes it away.

When an American visiting Mumbai wakes up missing a kidney, the investigation leads the team to suspect the unsub is up to more than trading organs on the black market.

The team turn their attention to Cairo, where an American ex-serviceman is killed in a gas attack, and his friend has gone missing.

In Japan, the team help local law enforcement investigate a string of homicides that have been made to look like suicides. Mae encourages Clara to take time to have fun.

The International Response Team travels to Paris to search for an unsub who is targeting Americans who live there.

Believing a honeymooning couple may have been abducted, the team head to Belize to investigate the disappearance.