Wandering cowboy Lucky Luke fights crime and injustice, most often the bumbling Dalton brothers, with his horse Jolly Jumper and dog Rantanplan.

While Buffalo Bill fights a rival for the record of greatest buffalo killer, Senator Hancock asks Lucky to escort a pair of zoo-raised orphan buffaloes to their natural habitat.

The Daltons dig a tunnel to escape from prison and take old Alfred Faria along because he knows the location of an ancient city with a legendary treasure.

Lucky protects the brothers Lumière, pioneers of cinematography, while they film the first Western ever made in Holly Woods.

Scam artist Elmer Rotten, man of a thousand tricks and disguises, escapes to the Wild West and decides Lucky Luke's identity is easy to steal.

When Queen Victoria visits President Grant, the two leaders end up making a wager about who can catch the Daltons first: Sherlock Holmes or Lucky Luke.