Meet Dottie the Body, who has struggled with her confidence after a large bump appeared between her thighs. A new, young doctor who joins Dr. Lee to assist Tim, a man dealing with a prominent, bumpy nose.

Dr. Lee and a medical student trainee help Emil and his wife, who are afraid the bump and lesion on his back might be cancerous.

Tierra is a musician with massive bumps on her ears that hold her back from performing. Dr. Zoe assists Dr. Lee helping Ryan, whose numerous head bumps undermine his life journey. Ann keeps a great attitude even as she lives with everyday pain caused by her genetic skin condition.

Dr. Lyndsey assists Dr. Lee with Lance's notoriously big bump that halted his rap dreams. Shelby has lost control of her sweet tooth, her health, and the mystery bumps she has developed. Dr. Lee proposes a long-shot cure for Jante, who has been losing pigment in her skin as well as her confidence.

Anthony is trying to move on from his troubled past, but his huge thigh lump is holding him back. Mary has a mysterious 70-year-old bump that amazes Drs. Lee and Tomassian. Sultana has a shocking red rash on her face that affects her social media success.

Dr. Lyndsey joins Dr. Lee to help David, who is fearful that the lump on his jaw might be cancer; Carla has a large, mysterious bulge on her thigh that concerns Dr. Lee.