Adam and Danielle Busby give birth to the first set of all girl quintuplets in the U.S., and have their lives turned upside down.

Adam and Danielle struggle to keep up with the quintuplets' demands while also making time for 4-year-old Blayke; a baby photo shoot turns into pure chaos when Grandma Mimi shows up late.

Adam returns to work, leaving Danielle to care for the quintuplets and Blayke by herself; Hazel gets a fever, leaving the family scrambling and Danielle feeling overwhelmed.

Adam and Danielle realize they need a larger home, but house hunting proves stressful when they factor in the cost; the family heads back to their hometown, and Danielle has an idea that could solve their problems.

Adam and Danielle have their hands full chasing after their 15-month-old quintuplets; a doctor recommends an extreme medical procedure for one of the girls, forcing the Busbys to make a difficult decision.

The Busbys take a road trip to Lake Charles to help Mimi with her garage sale, and Danielle learns some shocking news; Danielle and Adam wrestle with the decision to allow Hazel to have a risky eye surgery.