In 2008, 2-year-old Caylee Anthony is found dead in the woods near her family home in Florida just six months after she went missing. Her mother, Casey Anthony, becomes the prime suspect in her disappearance and subsequent murder and she is indicted on capital murder charges among others. Though many pieces of evidence are presented and dismissed by the defense, five key items during the investigation point to Casey Anthony. Viewers are invited to take a step back in time to explore the tragedy of Caylee Anthony with retired FBI supervisory special agent Jim Clemete and former New Scotland Yard criminal behavioral analyst Laura Richards.