The team is pushed to the limit when they are called to a train crash. On the train Anna becomes trapped, while Comfort tries to carry some school children to safety, and Lara is forced to chose between saving a mother or her baby. When an explosion is heard the team are left wondering who will and will not survive.

The team continue their battle to pull people from the train crash. Comfort's faith is destroyed when she fails to save the school children, Merlin rushes to Anna's side, at great potential cost, and back on the ward, a new face makes quite an impression.

The consequences of the train crash begin to hit home. Comfort struggles to come to terms with what has happened. And Jim warns Nikki not to get involved with Paul.

Simon is offered a high-flying pharmaceuticals job that looks like the perfect escape from his troubles at Holby.

Comfort faces a crisis of faith, and a new recruit turns up at Holby, ready to start work - but his arrival soon leaves Tess with a mystery to solve.

Josh is deeply distressed to learn that Colette is moving on with her life so quickly, romance may be on the horizon for Nikki again, and Tally has a passionate encounter.