Joshua Rush

While investigating a series of murders of entire families in Hampton, Virginia, the BAU is forced to visit Red Onion Supermax Prison to seek advice from one of the most atrocious killers from the team's past, nicknamed "The Fox," who delivers a portentous message to Agent Hotchner.

When remains of real estate agent Justin Ross are found in the forest and appear to have been destroyed by coyote-wolf hybrids, Brennan enlists the help of fellow brilliant forensic anthropologist Dr. Beth Mayer to assist in the investigation. In addition to her professional achievements, Mayer is surprisingly knowledgeable about the world of fantasy football, a key link to Ross’ past and one that could provide vital information in finding his killer. As Booth and Aubrey dig into Ross’ fantasy football league history, they discover he was actively involved in a Twitter feud with NFL star Lou Divers, and was also owed a large sum of money from the league’s commissioner, making each of them suspects. Meanwhile, Brennan resists feeling competitive as Mayer impresses the team with her expertise and decades of accomplishments.

The team believes a patient's problems are both physical and psychological; Foreman tries an alternative approach with House.

Cooper's patient comes in with the measles, which quarantines the practice; Dell fights for sole custody of his daughter, Betsy; Violet and Pete consider taking their relationship to the next level.

Clarence draws a comic for the school paper that's a big hit. When his parents censor the comic’s crass humor, Clarence stands up for his vision.