Audrey has a severe condition that leaves her with painful bumps on every inch of her body. An embarrassing armpit growth affects former marine Matt's self-esteem. Jaclyn has a lemon-sized bump on the back of her head.

Roger's case of rhinophyma is so extreme that he has difficulty breathing. The small, evenly spaced bumps all over Natalie's body are interfering with her life. Virginia thinks the equally sized lumps on her arms make her look like a football player.