Due to the global pandemic, Dr. Lee has started consulting with her patients through video chat. Monica's big, bumpy birthmark is taking over her neck. Shane has a firm bump precariously near his eye. Ellie's psoriasis is so severe that it clogs her ears.

Reginald hides the embarrassing growths on the back of his head with knitted hats. Jackie has lived with her huge shoulder lump for nine years. Leonardo has a chilling-looking growth on his head, but the thought of surgery terrifies him.

Fun-loving Che'Re has a squishy, dark bump on her cheek that has left her depressed and self-conscious. Buck has been breaking out in painful, fluid-filled blisters for three years. Telly developed a massive bump behind his head after being hit by a car.

Larry has a hanging thigh growth so large that the weight of it makes his leg go numb. Cheerleader Bailee has a disappearing back bump she has named Ralph. With three complicated skin conditions, Ashley's case is considered a "skin nightmare."

Audrey has a severe condition that leaves her with painful bumps on every inch of her body. An embarrassing armpit growth affects former marine Matt's self-esteem. Jaclyn has a lemon-sized bump on the back of her head.

Roger's case of rhinophyma is so extreme that he has difficulty breathing. The small, evenly spaced bumps all over Natalie's body are interfering with her life. Virginia thinks the equally sized lumps on her arms make her look like a football player.