Karen is coming home to her chosen family for Thanksgiving held on the 4th of July. She has cancer. Unbeknownst to all of them, it may be her last time.

Tom prepares for his upcoming singing engagement, and Karen has heartfelt talks with Roberta and Charlie. Meanwhile, Brendon is desperately trying to get to Karen.

Grace questions Paul's sexuality, Roberta and Donny commit to giving love a chance, and Star finds out why Brendon left the relationship. Roberta competes in the Slay Model Search and Tom performs at the Eagle.

All the couples join Karen for the big Thanksgiving dinner and Brendon shows up at last, just in time for 4th of July fireworks. A welcome phone call brings them hope for Karen's illness.