Dr. Beaumont Rosewood (Morris Chestnut), a brilliant private pathologist, uses his sophisticated lab to perform autopsies for the Miami Police Department, uncovering clues its staff couldn't see. The tough-as-nails Detective Villa (Jaina Lee Ortiz) serves as Rosewood's partner-in-crime, who is both impressed with Rosewood's incredible abilities and annoyed by his incessant optimism. Rosewood's positive outlook and his desire to live life to the fullest is based on a personal struggle with an array of medical issues, and the victims he encounters whose lives were abruptly shortened.