College student Alyssa looks forward to her senior year so she can finally hold her head up high, date a guy and have a "real" college experience after being born with a disabling genetic disorder that affected her smile. Baseball lover Mark plays a high stakes game to get the smile he has always wanted.

Aspiring beautician Melissa has never felt beautiful herself and her extreme fear of dentists drove her to give up a chance of a lifetime to have her smile fixed. Now, Melissa has a second chance. Will she overcome her fears and live the life she wants or will she fail again? Actress Megan is ready to take center stage after confronting years of shame over her rotting teeth.

Stepping into the "mom" role for her 9 siblings, Brooke neglected her teeth for years. Countless dentists said her mouth was hopeless and refused to help, but Dr. Glassman steps in to see if she can give Brooke the smile of her dreams.

Jacqueline looks to find closure from the brutal attack that stole her smile and almost cost her life. Single mom Crissy wants to step out of the shadows and teach her daughters how to live a life filled with self-esteem.

A star athlete with a winning personality, Nigel's life and mouth went off the rails when his front tooth was knocked out. After subsequent heartbreak and tragedy, Nigel is ready to prove he is the man he was meant to be. Julie's teeth are a "horror show" that have derailed her life and kept her daughter from leaving home.

Sarah wants nothing more than to start a family with her husband, but the infection coursing through her body stops her in her tracks. Will Sarah be able to face the pain in order to live her dream? Extreme athlete Chris has always wanted to take care of the problem that has haunted him every day for decades, but instead of taking care of himself he put his family first.